Effects of the degree of saturation of dietary fat on the hepatic production of lipoproteins in the African green monkey.
نویسندگان
چکیده
The cholesteryl ester content of plasma low density lipoproteins (LDL) in monkeys has previously been shown to be related to the rate of hepatic cholesterol secretion and cholesteryl ester content of newly secreted lipoproteins in the isolated perfused liver. In the present studies, African green monkeys were fed diets containing cholesterol and 40% of calories as either butter or safflower oil in order to determine the effects of saturated versus polyunsaturated dietary fat on hepatic lipoprotein secretion. The rate of cholesterol accumulation in liver perfusates was correlated with the size of the donor's plasma LDL, but for any rate, a smaller plasma LDL was found in donor animals of the safflower oil group than in those of the butter group. Hepatic very low density lipoproteins (VLDL) were smaller in the safflower oil group but contained more cholesteryl ester and fewer triglyceride molecules per particle than those from the butter group. Livers from the safflower oil group contained more cholesteryl ester and less triglyceride than those from the butter group. The cholesteryl ester percentage composition of hepatic VLDL resembled that of the liver in each group. The data show that dietary polyunsaturated fat decreased plasma LDL size even though it increased the cholesteryl ester content of lipoproteins secreted by the liver. Therefore, intravascular formation of plasma LDL from hepatic precursor lipoproteins appears to include the removal of relatively greater amounts of cholesteryl esters from the precursor lipoproteins in polyunsaturated fat-fed animals.
منابع مشابه
Effects of salinity on growth and fatty acid composition of green microalgae Dunaliella bardawil as a candidate source for biofuel production
Microalgae as a source of saturated and unsaturated fatty acids, pigments, pharmaceutical and food metabolites, has received more focus by biological researchers at last decades. The amount and composition of fatty acids produced by microalgae depended on biomass production and environmental factors such as changes in salinity, light and nutrient availability. In this study, the green microalga...
متن کاملمطالعه اثرات پیشگیرانه عصاره چای سبز از ابتلاء به استئاتوز کبد در موش‌های صحرایی تغذیه شده با جیره پر چرب
Background and Objective: Nonalcoholic fatty liver disease is one of the most common causes of chronic liver injury throughout the world. In this study, the preventive effects of green tea extract on fatty liver disease induced by high fat diet is assessed in the rats. Materials and Methods: In this experimental study, male Wistar rats were randomly divided to: Healthy control, Feeding...
متن کاملPerformance and Serum Hepatic Enzymes of Hy-Line W-36 Laying Hens Intoxicated with Dietary Carbon Tetrachloride
An experiment was conducted to study the effects of carbon tetrachloride (CCl4) on post-peak performance and serum enzymes of Hy-Line W-36 laying hens from 32-36 weeks of age. The experiment was carried out with a total of 192 laying hens in a completely randomized block design. During the experiment laying hens were allocated to 4 groups consisted of T1) no CCl4 as control diet, T2, T3 and T4)...
متن کاملThe Effect of Flaxseed oil and Ginger Powder on Fat Metabolism, Lipid Profiles and Liver Enzymes of Broilers
Extended Abstract Introduction and Objective: One of the major problems of mother herd industry is the accumulation of abdominal fats and increasing plasma fat index by furthering production period. These changes predispose chickens and roosters to metabolic diseases and fertility issues. The aim of this study was to investigate the effect of flaxseed oil and ginger powder on fat metabolism, l...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Journal of lipid research
دوره 26 4 شماره
صفحات -
تاریخ انتشار 1985